Now, I know at first this may seem a little confusing. Have no fear though. I shall explain!
There are two main hormones that are responsible for regulating your appetite, ghrelin and leptin. When you’re hungry or full, your brain gets the message from your body via many nervous and hormonal feedback mechanisms. Thus, when given the right stimulus, ghrelin or leptin is secreted into the blood.
When you’re HUNGRY, your brain signals your stomach to contract. This causes the secretion of ghrelin from specialized cells found in your stomach and pancreas – circulating levels of ghrelin INCREASES appetite.
When you’re FULL, your brain primarily stimulates your fat cells (or adipocytes) to secrete leptin – circulating levels of leptin SUPPRESSES appetite and breaks down stored fat cells.
So, how does being overweight relate to any of this?! Well, when an individual accumulates too many fat cells (or becomes overweight), it causes these cells to secrete something called c-reactive protein. This is VERY significant because as c-reactive protein binds to circulating leptin, it INHIBITS leptin from entering the brain. This further prevents the brain from sensing satiety and thus, encourages us to eat more as we become leptin resistant.
Here’s a visual aid for you:

The disruption of communication between the brain and its hormonal response to leptin is quite detrimental as it increases appetite regardless of satiety.
P.S. I found this really cool video describing this concept in further detail. Enjoy!






Thank you for the sensible critique. Me and my neighbor were just preparing to do a little research on this. We got a grab a book from our area library but I think I learned more from this post. I am very glad to see such great information being shared freely out there.
Hello! I just wanted to thank you for sharing your thoughts and I’m really glad the information helped you. It is simple comments like these that drive the growth of this blog. Again, thank you and be well!
Your post, Being Overweight Encourages Appetite | Nutrition and Exercise Understood, is really well written and insightful. Glad I found your website, warm regards!
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Glad you stopped by Lavenia. Have a great holiday!
I really liked this blog. I think your content is actually actually great.
But I found the post title a little mundane! I think you truly are able to enhance on the headline by referencing just how the best bloggers do it. It is actually a shame that you do not get adequate exposure just because of your blog post headlines. Also, why are there countless spammers over here commenting on your post?
Todd, all I can say is wow. I can’t thank you enough for your input, like…seriously lol. I definitely have to do some research and experimentation on creating titles that better captures attention. Its a slow beginning but with more tips like yours, I’ll make it work
. Oh and about those spammers? I have NO idea man. Seems like with each new post, hot damn! Again, can’t thank you enough and hope all is well! Take care.